ampk activator 13 Search Results


ampk activator 13  (MedChemExpress)
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MedChemExpress ampk activator 13
SBEM induces PTX resistance in breast cancer cells by activating the AMPK pathway. (A) Flow cytometry analysis of apoptosis in SUM190PT/PTX cells transfected with siRNA for 48 h and treated with AMPK <t>activator</t> <t>13</t> (5 µmol/l) for 24 h. (B) The treatment of SUM190PT/PTX cells was the same as aforementioned. After the treatment, the change in cell viability was determined by the CCK-8 assay. (C) The treatment of SUM190PT/PTX cells was the same as aforementioned. After the treatment, the relative expression levels of Bax, Bcl2, Caspase-3 and cleaved-Caspase-3 proteins were detected by western blotting. **P<0.01, ***P<0.001, ****P<0.0001. ns, not significant; PTX, paclitaxel; SBEM, small breast epithelial mucin; CCK-8, Cell Counting Kit-8; si, small interfering (RNA).
Ampk Activator 13, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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SBEM induces PTX resistance in breast cancer cells by activating the AMPK pathway. (A) Flow cytometry analysis of apoptosis in SUM190PT/PTX cells transfected with siRNA for 48 h and treated with AMPK activator 13 (5 µmol/l) for 24 h. (B) The treatment of SUM190PT/PTX cells was the same as aforementioned. After the treatment, the change in cell viability was determined by the CCK-8 assay. (C) The treatment of SUM190PT/PTX cells was the same as aforementioned. After the treatment, the relative expression levels of Bax, Bcl2, Caspase-3 and cleaved-Caspase-3 proteins were detected by western blotting. **P<0.01, ***P<0.001, ****P<0.0001. ns, not significant; PTX, paclitaxel; SBEM, small breast epithelial mucin; CCK-8, Cell Counting Kit-8; si, small interfering (RNA).

Journal: Oncology Letters

Article Title: SBEM confers paclitaxel resistance in breast cancer via DUSP16-mediated MAPK/AMPK pathway activation

doi: 10.3892/ol.2025.15353

Figure Lengend Snippet: SBEM induces PTX resistance in breast cancer cells by activating the AMPK pathway. (A) Flow cytometry analysis of apoptosis in SUM190PT/PTX cells transfected with siRNA for 48 h and treated with AMPK activator 13 (5 µmol/l) for 24 h. (B) The treatment of SUM190PT/PTX cells was the same as aforementioned. After the treatment, the change in cell viability was determined by the CCK-8 assay. (C) The treatment of SUM190PT/PTX cells was the same as aforementioned. After the treatment, the relative expression levels of Bax, Bcl2, Caspase-3 and cleaved-Caspase-3 proteins were detected by western blotting. **P<0.01, ***P<0.001, ****P<0.0001. ns, not significant; PTX, paclitaxel; SBEM, small breast epithelial mucin; CCK-8, Cell Counting Kit-8; si, small interfering (RNA).

Article Snippet: AMPK activator 13 (MedChemExpress; cat. no. HY-155363), an AMPK signaling pathway activator , was used to investigate the role of SBEM in regulating AMPK signaling.

Techniques: Flow Cytometry, Transfection, CCK-8 Assay, Expressing, Western Blot, Cell Counting, Small Interfering RNA

AMPK activator 13 restores drug sensitivity to PTX. Western blotting of DUSP16, p-DUSP16, MAPK, p-MAPK and SBEM protein levels in SUM190PT/PTX cells transfected with siRNA for 48 h and treated with AMPK activator 13 for 24 h. **P<0.01, ***P<0.001, ****P<0.0001. ns, not significant; PTX, paclitaxel; SBEM, small breast epithelial mucin; DUSP16, dual specificity phosphatase 16; p-, phosphorylated; si, small interfering (RNA).

Journal: Oncology Letters

Article Title: SBEM confers paclitaxel resistance in breast cancer via DUSP16-mediated MAPK/AMPK pathway activation

doi: 10.3892/ol.2025.15353

Figure Lengend Snippet: AMPK activator 13 restores drug sensitivity to PTX. Western blotting of DUSP16, p-DUSP16, MAPK, p-MAPK and SBEM protein levels in SUM190PT/PTX cells transfected with siRNA for 48 h and treated with AMPK activator 13 for 24 h. **P<0.01, ***P<0.001, ****P<0.0001. ns, not significant; PTX, paclitaxel; SBEM, small breast epithelial mucin; DUSP16, dual specificity phosphatase 16; p-, phosphorylated; si, small interfering (RNA).

Article Snippet: AMPK activator 13 (MedChemExpress; cat. no. HY-155363), an AMPK signaling pathway activator , was used to investigate the role of SBEM in regulating AMPK signaling.

Techniques: Western Blot, Transfection, Small Interfering RNA